Posts tagged: chronic rhinosinusitis

Photodisinfection for Refractory Chronic Rhinosinusitis Patients: A much needed advance for an under-served patient population

Chronic rhinosinusitis (CRS) is one of the most common chronic conditions in the United States. There is a significant subpopulation of CRS patients who remain resistant to cure despite rigorous treatment regimens including surgery, allergy therapy, and prolonged antibiotic therapy. This refractory patient population is thought to exceed 500,000 in the US.

Photodisinfection, also known as antimicrobial photodynamic therapy (aPDT), is a noninvasive, non-antibiotic broad spectrum antimicrobial treatment that can improve outcomes for this under-served patient population by reducing inflammation of sinus tissue and eliminating biofilm in the sinuses. Patients  suffering from refractory Chronic Rhinosinusitis are likely to be infected by super-antigen producing bacterial such as Staph aureus and Pseudomonas aeruginosa. Photodisinfection has been proven to be highly effective at targeting these two pathogens and inactivating inflammatory cytokines.

How Do I Know I Have Chronic Sinusitis?

As a first year medical student, cancer and HIV/AIDS are two common illnesses that I without a doubt will encounter in my line of work. However, not many people know about chronic rhinosinusitis, or simply known as chronic sinusitis, which also affects many people. Each year, 37 million Americans are faced with combating a case of sinusitis, the fifth most common disease treated with antibiotics [1,2].

What exactly is chronic sinusitis? It is an inflammation of the tissue in our sinuses, the cavities around our eyes, nose, cheeks, and forehead. Usually they are full of air but due to various causes these spaces become filled with viruses, bacteria, and fungi.

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